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Translate this page into: Predictors of disease severity in drug reaction with eosinophilia and systemic symptoms 1 , Anuradha Thalian Chathoth 2 , Anza Khader 1 , Olasseri K Reena Mariyath 1 , Najeeba Riyaz 1 , Manikoth Payyanadan Binitha 1 , Kunnummal Muhammed 1 , Biju George 3 , Parvathy Santhosh 1 , Sangeetha Roslind 1 , Nina Paul 1 , Mithun Harold Thomas 4 1 Department of Dermatology and Venereology, Government Medical College, Kozhikode, Kerala, India 2 Health Services, Koyilandy Taluk Hospital, Kozhikode, Kerala, India, India 3 Department of Social and Preventive Medicine, Government Medical College, Kozhikode, Kerala, India 4 General Medicine, Government Medical College, Kozhikode, Kerala, India Correspondence Address : Sarita Sasidharanpillai Rohini, Girish Nagar, Nallalom PO, Kozhikode - 673 027, Kerala India Abstract Background: Drug reaction with eosinophilia and systemic symptoms is an outcome of a complex interaction between specific drugs, certain herpesviruse types and the immune system of the affected individual and is characterized by an unpredictable course and recurrent flares even after withdrawal of the offending drug and administration of systemic steroids

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