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In terms of mechanism, the implicated drug is believed to interact with its specific HLA to form a hapten-HLA complex, which is then presented to T nave cells (TH0), via a T-Cell Receptor (TCR) to stimulate an immune response.19 It is important to highlight that the associations between the risk of a given drug and a specific HLA have a high negative predictive value and moderate to low Positive Predictive Values (PPV)
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Clinically, it is a rare, potentially life-threatening, febrile drug reaction (hypersensitivity syndrome) with exanthema and variable blood eosinophilia and elevation of liver enzymes
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